Banumathi Sankaran Selected Research

Neoplasms (Cancer)

2/2024	Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy.
1/2023	Computational design of constitutively active cGAS.
1/2022	Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
1/2021	Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
1/2020	Minimally disruptive optical control of protein tyrosine phosphatase 1B.
1/2019	Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition.
1/2016	Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
11/2014	Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.
9/2011	Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.

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Banumathi Sankaran Research Topics

Disease

9	Neoplasms (Cancer) 02/2024 - 09/2011
7	COVID-19 08/2023 - 07/2020
5	Infections 10/2023 - 06/2014
4	Human Influenza (Influenza) 01/2024 - 11/2019
4	Gastroenteritis 10/2023 - 09/2011
4	Virus Diseases (Viral Diseases) 08/2023 - 04/2014
4	Bites and Stings (Sting) 01/2023 - 07/2013
2	Carcinogenesis 01/2023 - 01/2021
2	Malaria 01/2023 - 09/2011
2	Communicable Diseases (Infectious Diseases) 01/2017 - 09/2011
2	Vascular System Injuries 06/2016 - 02/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2023
1	Cryptosporidiosis 10/2023
1	Gram-Negative Bacterial Infections 01/2021
1	Obesity 01/2020
1	Hyperalgesia 01/2018
1	Pain (Aches) 01/2018
1	Chronic Pain 01/2018
1	Hemorrhage 06/2016
1	von Willebrand Diseases (von Willebrand's Disease) 06/2016
1	Type 2 von Willebrand Disease 02/2016
1	Cat-Scratch Disease 01/2016
1	Erectile Dysfunction 01/2016
1	Methylmalonic acidemia 06/2015
1	Tuberculosis (Tuberculoses) 06/2015
1	Diarrhea 12/2014
1	Botulism 07/2013
1	Babesiosis (Piroplasmosis) 09/2011
1	Starvation 11/2009

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2023 - 07/2013
7	Antiviral Agents (Antivirals)IBA 01/2024 - 04/2014
7	EnzymesIBA 12/2023 - 01/2019
4	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 07/2013
4	Peptide Hydrolases (Proteases)FDA Link 10/2022 - 01/2016
2	EndonucleasesIBA 01/2024 - 01/2023
2	VaccinesIBA 10/2023 - 10/2023
2	SARS-CoV-2 3C-like proteinaseIBA 08/2023 - 12/2021
2	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2023 - 01/2019
2	InterferonsIBA 01/2023 - 04/2014
2	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 10/2022 - 12/2021
2	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 01/2019
2	Polysaccharides (Glycans)IBA 01/2022 - 09/2015
2	Peptides (Polypeptides)IBA 01/2021 - 07/2020
2	LigandsIBA 11/2019 - 01/2017
2	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2018 - 01/2016
2	Hemostatics (Antihemorrhagics)IBA 06/2016 - 02/2016
2	von Willebrand FactorIBA 06/2016 - 02/2016
2	Blood Group Antigens (Blood Groups)IBA 06/2014 - 09/2011
1	Tyrosine (L-Tyrosine)FDA Link 02/2024
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 02/2024
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2024
1	Protein Tyrosine PhosphatasesIBA 02/2024
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2024
1	Oseltamivir (Tamiflu)FDA Link 01/2024
1	baloxavirIBA 01/2024
1	Zanamivir (Relenza)FDA Link 01/2024
1	LactamsIBA 12/2023
1	EpitopesIBA 10/2023
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/2023
1	Carboxylic AcidsIBA 01/2023
1	Pattern Recognition ReceptorsIBA 01/2023
1	glycylpeptide N-tetradecanoyltransferaseIBA 01/2023
1	Galectins (Galectin)IBA 01/2022
1	Contraceptive Agents (Contraceptives)IBA 01/2021
1	Klebsiella pneumoniae carbapenemase-2IBA 01/2021
1	Small Molecule LibrariesIBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2020
1	tyrosine receptor (receptor, tyrosine)IBA 01/2020
1	Hemagglutinins (Hemagglutinin)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Viral VaccinesIBA 01/2020
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 01/2020
1	Interferon Type IIBA 01/2019
1	Nucleic AcidsIBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	ophiocordinIBA 01/2018
1	Amino Acids FDA Link 01/2017
1	Adenosine Triphosphate (ATP)IBA 01/2017
1	Ligases (Synthetase)IBA 01/2017
1	Transfer RNA (tRNA)IBA 01/2017
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2016
1	4-hydroxy-tetrahydrodipicolinate synthase (dihydrodipicolinate synthase)IBA 01/2016
1	Virulence Factors (Pathogenicity Factors)IBA 12/2014
1	Acyl Carrier ProteinIBA 11/2014
1	Triclosan (pHisoHex)FDA Link 11/2014
1	Oxidoreductases (Dehydrogenase)IBA 11/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 11/2014
1	Botulinum Toxins (Botulinum Toxin)IBA 07/2013
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 09/2011
1	Thymidylate SynthaseIBA 09/2011
1	Folic Acid (Vitamin M)FDA LinkGeneric 11/2009

Therapy/Procedure

4	Therapeutics 02/2024 - 01/2016
1	Drug Therapy (Chemotherapy) 09/2011